MARIJUANA WEIGHT LOSS THEORY

A unique hypothesis put out by researchers at the Cannabis and Cannabinoid Research Institute holds that the high omega-6/omega-3 fatty acid ratio in the typical American diet has a reversible effect on endocannabinoid tone when cannabis is used (particularly THC). To get 420 evaluations follow the link.

The gist of it is as follows:

A high omega-6/omega-3 ratio is a consequence of the typical American diet, which is high in sweets and processed grains. To get 420 evaluations jacksonville follow the link.

CB1 receptors are stimulated by cannabinoids named AEA and 2-AG, which are made from omega-6 fatty acids. Addiction and metabolism are heavily controlled by CB1 receptors. For 420 evaluations miami follow the link.

AEA and 2-AG production increases as the omega-6/omega-3 ratio rises. This results in increased hunger and metabolic dysfunction due to the activation of CB1 receptors.

THC, the active ingredient in cannabis, reduces CB1 activation. Although marijuana produces an initial up-regulation (when users feel the "munchies"), it swiftly changes to affect longer-lasting down-regulation behavior....

However, why is THC so crucial?

THC, unlike other phytocannabinoids, can bind directly to CB1 receptors, making it the most potent cannabinoid we know of. To get 420 evaluations tampa follow the link.

Receptors for THC

As the authors of the study explain, the new hypothesis addresses many of the issues raised by prior studies.

As various people eat different diets, this idea may explain the discrepancies between research on the effects of cannabis on metabolic dysregulation because of this.

To illustrate this point, epidemiological studies of the effects of cannabis usage on Swedish conscripts may provide different findings from epidemiological studies in the United States because of the differing obesity rates in the two nations.

While medicinal marijuana and cannabis-based medications like Marinol may boost appetite and weight growth in individuals with anorexia or wasting, they can also cause weight loss in other people. This logic discusses this subject. To get mmj certifications follow the link.

CB1 receptors are up-regulated when THC is used to stimulate them (meaning most patients will experience an increase in appetite and calorie consumption). However, patients who need to gain weight are likely to have a much different omega-6/omega-3 ratio starting point than patients who need to lose weight, which means that as CB1 behavior shifts to down-regulation, the balancing of these two fatty acids will result in different outcomes for each individual patient.

To put it another way, weight gain is more likely among people who use cannabis regularly but who don't consume an excessive number of calories, since their bodies are better able to burn or store those calories when they aren't as starved.

MARIJUANA WEIGHT LOSS TIPS

What are the implications of all this research for patients? When it comes to losing weight, how can you utilize medicinal marijuana?

The current hypothesis emphasizes the significance of THC in studying marijuana's function in weight reduction. According to current research, THC is the primary cannabinoid that binds directly to CB1 receptors in the body. THC ingestion is assumed to be the cause of the behavioral and physiological changes mentioned in this article.

According to the study's authors:

According to our hypothesis, cannabis-induced weight loss may require the psychoactive effects of THC stimulation of CB1 receptors in addition to the weight loss itself. This is because a decrease in BMI necessitates a decrease in CB1 receptor activity and whether microdosing causes this decrease is not yet known.

Weekly or biweekly cannabis use, on the other hand, may be adequate, since BMI drops significantly with weekly use.

In addition, researchers have noted:

Cannabis may be a better alternative for weight reduction for many individuals than surgery or medicines, according to a recent study. While cannabis are safe for most individuals, those with underlying cardiovascular diseases or previous myocardial violations should take care.

No "to-do" list is provided by the research authors, but if their hypothesis is correct, they do offer a number of predictions that may assist in the pursuit of weight loss:

During periods of abstinence, chronic cannabis users may shed more pounds.

Because CB1 receptors remain down-regulated for many weeks after chronic cannabis intake, BMI should drop even more when users quit using cannabis. Those who have been recently abstinent will have a decreased hunger and an enhanced metabolism at this time. Because of this, they will not experience the "munchies," energy consumption and storage, and decreased metabolic rates throughout each acute cannabis use session. When the CB1 receptors revert to pre-marijuana levels, weight loss will accelerate as energy intake and storage remain suppressed and metabolism is boosted.

The DSM-V, the American Psychiatric Association's handbook, lists weight loss as one of the seven symptoms of "cannabis withdrawal," and this prediction is backed by this fact.

Prediction 2: Depending on the omega-6/omega-3 ratios, various diets may provide different effects.

Dietary effects on the endocannabinoid system are projected to vary depending on the quantity of green vegetables, industrially produced animals, marine seafood, and processed foods consumed by various cultures. To put it another way, the current idea holds that those who consume more sugar and refined carbohydrates than those who consume more omega-6/omega-3 fatty acids will benefit from cannabis usage more than those who do not.

Omega-3 supplements and cannabis might be a very beneficial therapy, according to Prediction 3.

A combination of omega-3 supplementation and cannabis usage is expected to have a greater impact on decreasing BMI and cardiometabolic risk factors than either option alone.

Importantly:

Weekly cannabis usage may be sufficient to see considerable weight reduction and metabolic advantages since CB1 receptors stay down-regulated for some time after use.

Omega-3 fatty acid supplements and cannabis usage are predicted to have a comparable but not equal effect on health.

The CB1 RECEPTOR WEIGHT LOSS DRUGS include

Pharmaceutical companies have already begun investigating CB1 receptor medications as possible weight loss weapons, which is understandable.

Rimonabant, a selective CB1 antagonist/inverse agonist, was licensed for the treatment of obesity in 30 countries in 2006. There were some serious adverse effects, such as dizziness, anxiety and sadness that led to the withdrawal of medicine some years later.

Peripherally limited CB1 receptor antagonists are being studied in the hope of providing therapeutic advantages for obesity without the same mental adverse effects as currently available treatments.

According to studies:

The endocannabinoid system plays a major role in many treatment approaches, but one that doesn't induce significant mental side effects while still acting peripherally is of particular relevance. CB1 receptor antagonists such as URB447 and AM6545 are showing promising results...

IN THE END,

Despite the complexity of the research presented above, the most important takeaway is this:

The usual American diet (which includes a lot of sugar and processed carbohydrates) may be causing an imbalance in our endocannabinoid system, which might be corrected by a marijuana ingredient called THC, according to researchers. This could lead to weight reduction. Marijuana use may temporarily increase hunger, but it has a long-term effect on our body's ability to burn and store calories more effectively. Patients' appetites may also be affected. Individuals may lose even more weight in the three to four weeks after cessation of cannabis usage due of these long-lasting effects (because the benefits are still in play, but the short-term spikes in appetite are missing).

omega-3:omega-6 fatty acid ratio has been shown to have an effect on weight reduction. Researchers believe that supplementing with omega-3 fatty acids, in addition to cannabis therapy, might give an even larger benefit by canceling out or reducing the issues associated with a high omega-6 to omega-3 ratio.

According to what they found, researchers say:

Endocannabinoid system dysfunction may be a major contributor to a wide range of significant medical problems.

As a result of a high omega-6/omega-3 ratio in the American diet, cannabis usage in America seems to have major public health advantages.

Current meta-analysis shows substantial evidence that cannabis usage and/or THC exposure resulted in a lower BMI (BMI).

Scientists have been rushing to clarify and investigate the more complicated parts of today's issue, but the most essential message is clear: This idea is still a theory.

Medical marijuana is effective. And it's helping a lot of people lose weight and go on the path to a better and happier life all throughout the nation.

BMI CALCULATING

According to the Centers for Disease Control and Prevention (CDC), being overweight or obese is a medical condition in and of itself. BMI is the standard by which all medical conditions are evaluated (BMI).

Physicians working at CannaMD are delighted to help patients who are dealing with both diseases. Please use the CDC-approved calculator below to find out whether your BMI is considered overweight or obese:

You may be qualified for medicinal marijuana therapy if your BMI falls into one of the following categories: